The drugs .... intervene on body weight? - Dr. Claudia Bottino

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Drugs….intervene on body weight?

The answer is yes.

The correlation between weight alterations and certain pharmacological assumptions, inevitably it leads us to the control of food, for quantity and especially the type and quality, especially when drug treatments continue over time. When you begin a proper feed path, it is necessary to report which drugs are used and it will be the responsibility of the biologist-nutritionist, investigate during the anamnesis with the patient. By underestimating this aspect you risk not acting correctly with the dietary program, because some drugs, with different mechanisms, they hinder the system “burns fat” at an organic level and represent a risk for obesity. For example, some act at the hypothalamic level, altering the sense of hunger and satiety. Others induce excessive food choice , but let's see what they are:

-CYTOTOXIC DRUGS used to treat breast cancer, especially in pre-menopausal women, in patients receiving various cytotoxic drugs and in patients treated for long periods, we consider that these patients sometimes have a reduction in physical activity during treatment and this seems to contribute to weight gain.
-STEROIDS cause weight gain, especially because they stimulate the appetite. During long-term therapy, they cause a distribution of body fat more concentrated on the neck and upper trunk.
-BETA BLOCKERS they alter glucose metabolism and interfere with insulin regulation. Weight gain was observed primarily with propranolol. (Inderal)
-INSULIN in type diabetes 2, frequently causes weight gain, especially during intensive treatment. Patients with type diabetes 2 have weight gain during the first months of insulin therapy. The reduction in glycosuria for which the patient is probably also responsible , especially if decompensated, eats more food. The same thing happens if you use too much insulin and the resulting hypoglycemia, leads to food intake including sugars.
-HORMONES contraceptives and progestins cause weight gain and/or difficulty maintaining weight homeostasis in case of diet
-ANTIDEPRESSANTS tricyclics, such as amitriptyline and doxepin, they frequently cause weight gain, especially during the first months of treatment. The extent of weight gain appears to depend on the dose and duration of treatment….although benzodiazepines can have the double yo-yo effect , in fact, let's not forget that anxiety can change eating behavior, leading to both weight loss and gain
( anxiolytic effects )
-ANTIHYPERTENSIVE DRUGS like diuretics, calcium antagonists, beta-blockers, and alpha-adrenergic blockers can promote weight gain by generally increasing appetite. Particularly beta blockers, cause weight gain through different mechanisms : patients consume fewer calories during physical activity due to a reduced cardiac capacity for effort. Or by increasing the sense of tiredness they lead patients to move less; or they make patients select less healthy, calorie-rich foods as a consequence of their negative effect on mood.
These are just examples , but think over the course of a lifetime , how many drugs acted on the metabolic rate, maybe sometimes you even thought that there was no possibility for you to reshape your body, freeing it from accumulated fat.
Well, the technique exists and must be evaluated on a case-by-case basis, taking into account the fact that, if treatment is necessary and cannot be eliminated, an appropriate dietary pattern can, albeit not quickly, help the body towards weight homeostasis.

I want to remind you that drugs are not “candies” but rather molecules that we introduce into our organism and leave their positive effects here (on the pathology) and collateral and unwanted, therefore they must be taken carefully and appropriately, obesity can also be a side effect, so in that case….we move from one pathology to another! Pay attention.