ANTI-INFLAMMATORY DRUGS, to choose and why ?

The paracetamol (Tachipirina) it is more an antipyretic drug, lowers the fever , as it acts at the level of the central nervous system by blocking the formation of prostaglandins which influence body temperature. This is the effect that paracetamol taken in low doses has (500 mg) while that at high dosages (1g) it is used as a pain reliever in the treatment of toothache, headache, stiff neck, lumbosacral pain, minor pains from surgery. In addition to, the pain-relieving activity of paracetamol can be enhanced by combining codeine as in the case of Tachidol;

Ketorolac (Toradol), diclofenac (Voltaren) e piroxicam (Feldene) they are all widely used anti-inflammatories for the treatment of joint pain such as osteoarticular pain, ankylosing spondylitis, lombosciatalgie, post-operative pain, gotta. These drugs are very active and effective by injection and their administration requires an accurate medical examination;

Ibuprofen (Nurofen), ketoprofene (Oki) and asked (Momendol) are drugs used both to treat small aches such as menstrual pain and tooth pain, while at higher dosages they are used to treat more severe pains such as joint pains;

Nimesulide (Aulin) it is a more selective drug for COX-2 and is widely used for the treatment of severe pain. This drug, however, has a strong hepatotoxicity , damages the liver, and its use has been downsized.

The choice of the most suitable anti-inflammatory is the task of the specialist who must take into account the patient's state of health. All NSAIDs are gastrolesive therefore during the protracted therapies over time it is necessary to associate a gastric protection.

Steroidal anti-inflammatory drugs, better known as cortisone (and also called corticosteroids), are drugs made up of molecules that, from a structural point of view, they are analogous to cortisol, a hormone produced by the cortex of the adrenal glands. I cortisonici (corticosteroids), also known as steroidal anti-inflammatory drugs, they consist of molecules structurally similar to cortisol, a hormone synthesized and secreted by the adrenal gland (a small gland located at the apex of the kidney) starting from cholesterol. Cortisol is involved in many biological activities including regulation of blood sugar and protein metabolism. For his supervision of blood glucose levels, cortisol is also called glucocorticoid hormone (the "corticoid" suffix is ​​due to the fact that this hormone is produced in the "cortical" part of the adrenal gland that is found , as its name says , above the kidney; Cortisol also plays an important role in inflammatory processes. In fact, it controls the activity of phospholipase A2, the enzyme that transforms the phospholipids of cell membranes into arachidonic acid, precursor to other chemical mediators of inflammation such as prostaglandins and thromboxanes.

THE SIDE EFFECTS of cortisone they are of various kinds, especially when the drug is administered for a long time and at high dosages. Hyperglycaemia is one of the damages found, weight gain, hypertension, the ulcer, l’acne, insomnia and mood swings. A therapy based on the use of cortisone can be considered prolonged over time if it exceeds one month. In any case, even two weeks of treatment cannot be neglected as regards the possible side effects that can occur. Typically therapies that last for a few days or that concern emergency cases, even to combat asthma attacks and acute bronchitis they are not harmful.
However, one wonders if anti-inflammatory drugs are bad for the heart. Unfortunately, the side effects are different and subjective from person to person.

Who knows if you've read everything ?! I have taken the information on several pharmaceutical sites …I hope it was interesting!